Fenway Park has been the home of the Boston Red Sox since 1912. Because of its age and constrained location in Boston's dense Fenway-Kenmore neighborhood, the park has been renovated or expanded many times, resulting in quirky features including "The Triangle," Pesky's Pole, and the Green Monster in left field.

For seven seasons, the Boston AL team wore dark blue stockings and had no official nickname. They were simply "Boston", "Bostonians" or "the Bostons" or the "Boston Americans" (as in "American Leaguers"), Boston being a two-team city. Their 1901-1907 jerseys, both home, and road, just read "Boston", except for 1902 when they sported large letters "B" and "A" denoting "Boston" and "American." Newspaper writers of the time used other nicknames for the club, including "Somersets" (for owner Charles Somers), "Plymouth Rocks", "Beaneaters", the "Collinsites" (for manager Jimmy Collins)", and "Pilgrims."

The Red Sox were a dominant team in the newly formed American League, defeating the Pittsburgh Pirates in the first World Series in 1903 and winning four more championships by 1918.

Legend has it that Frazee traded Ruth for for $125,000 in order to finance the Broadway play No, No, Nanette. That play did not actually open on Broadway until 1925, but as Leigh Montville discovered during research for his book, The Big Bam: The Life and Times of Babe Ruth, No, No, Nanette had originated as a non-musical stage play called My Lady Friends, which opened on Broadway in December 1919. My Lady Friends had, indeed, been financed by the Ruth sale to the Yankees.

Mookie Betts finished the 2018 season leading the major leagues with a .346 batting average, a .640 slugging percentage, and 129 runs scored. He had the highest fielding percentage among major league right fielders at .996. The Red Sox finished the year at 108-54, and went on to win the World Series over the Los Angeles Dodgers.

On October 27, 2004, the Red Sox won the World Series for the first time since 1918, finally vanquishing the so-called "Curse of the Bambino" that had plagued them for 86 years. Before Ruth left Boston, the Red Sox had won five of the first fifteen World Series. The Yankees had not played in any World Series prior to acquiring Ruth, but in the 84 years after the sale, they appeared in 39 World Series, winning 26 of them, twice as many as any other team in Major League Baseball.

Between 1910 and 1915, Harry Hooper teamed up with Duffy Lewis and Tris Speaker to form the Golden Outfield, one of the best outfield trios in baseball history.

Jacob Ellsbury finished the 2009 season with 70 stolen bases, the most in the American League. He also led the league in triples with 10.

Tris Speaker played so shallow in the outfield that he was able to execute six career unassisted double plays at second base, catching low line drives on the run and then beating baserunners to the bag. No other outfielder has ever had more than two during their career.

In Game 6, first baseman Bill Buckner let a ball roll between his legs and into shallow right field, allowing the Mets to score the winning run from second base. Regardless of any of the other shortcomings that led to Boston's loss in the Series, Buckner's error epitomized the "Curse of the Bambino" in the minds of Red Sox fans, and he became the scapegoat for a frustrated fan base.