During his first season (1970-71), Gilbert Perreault led the Sabres in scoring (with 38 goals and 34 assists) -- a feat he would never fail to accomplish in any season in which he did not miss significant time to injury before his penultimate year -- and won the Calder Trophy as Rookie of the Year.

In 2006-07, his first full season as the Sabres starting goalie, Ryan Miller won 40 of 63 games, posting a 0.911 save percentage and a 2.72 GAA.

In 1992-93, Pat LaFontaine recorded a personal-best and team-record 148 points (53 goals and 95 assists) -- the most points ever scored by an American-born player in one season.

The Chicago Blackhawks traded Hašek to Buffalo for goalie Stéphane Beauregard and future considerations, which later materialized into a draft pick used to obtain Éric Dazé. He was initially the backup goaltender, but when Grant Fuhr when down with an injury during the 1993-94 season, Hašek was elevated to starter and quickly developed into a top-tier goaltender, winning his first Vezina Trophy that same year.

The 1992-93 season was a banner year for Alexander Mogilny, as he scored an astonishing 76 goals and 127 points in 77 games. His 76 goals tied Finnish rookie Teemu Selänne for the NHL goal-scoring lead that year and marked the first time a European player led the league in goals.

Led by Rob Ray's 354 penalty minutes, the 1991-92 Buffalo Sabres set an NHL record for team penalty minutes in a season, with 2,713.

Gilbert Perreault's seven-point game (2 goals and 5 assists) against the California Golden Seals on February 1, 1976 is a franchise record.

On 1 October 2013, Buffalo named Thomas Vanek and Steve Ott captains. Vanek would wear the "C" for home games while Ott would wear the "C" for road games.

Gare's number 18 is one of the handful of jerseys that hang in the rafters in Buffalo. He was a very productive, scrappy player for the Sabres during the 1970s and early 1980s. Twice a 50-goal scorer, he tied for the league lead with 56 in the 1979-80 season.

Don Luce had his best statistical season in 1974-75 when he set career highs in goals (33), points (76), shorthanded goals (8), and plus minus with a +61 rating.