Patrick was born on September 17, 1995, in Tyler, Texas.

Patrick's full name is Patrick Lavon Mahomes II.

When Mahomes was growing up, his father nicknamed him "Showtime" because of his athletic skill.

As a senior at Whitehouse High School, Patrick had 4,619 passing yards, 50 passing touchdowns, 948 rushing yards, and 15 rushing touchdowns. He was named the Maxpreps Male Athlete of the Year for 2013-2014.

In 2014, Mahomes entered his freshman season at Texas Tech as a backup to Davis Webb. He saw his first career action against Oklahoma State after Webb left the game with an injury, completing two of five passes for 20 yards for one touchdown and an interception. After Webb was again injured, Mahomes got his first career start against Texas, completing 13 of 21 passes for 109 yards, and remained the starter for the season's final three games. Against Baylor, he threw for a Big 12 freshman record 598 yards with six touchdowns. For the season, he passed for 1,547 yards, 16 touchdowns, and four interceptions.

Mahomes split time with the Texas Tech baseball team, where he was a relief pitcher.

Mahomes finished the 2016 season leading the country in yards per game (421), passing yards (5,052), total offense (5,312), points responsible for (318), and total touchdowns (53). For his performance, he was awarded the Sammy Baugh Trophy, given annually to the nation's top college passer, joining head coach Kliff Kingsbury, Graham Harrell, and B. J. Symons as other Red Raiders to have won the award.

The Chiefs, originally slated to have the 27th overall selection, traded up in the draft with the Buffalo Bills for the 10th overall selection, making Mahomes the second QB taken after Mitchell Trubisky (2nd Pick).

Three years before Patrick Mahomes was selected 10th overall by the Kansas City Chiefs in the 2017 NFL Draft, the Detroit Tigers selected the multi-sport athlete in the 37th round of the MLB Draft.

The Chiefs announced on December 27, 2017, that with a playoff spot and the fourth seed in the playoffs secured, they would rest starter Alex Smith and give Mahomes his first career start in their week 17 game against the Denver Broncos. Mahomes played most of the game and led the Chiefs to a 27-24 win, completing 22 of 35 passes for 284 yards and one interception.