Although it was originally set in an unnamed fictional city, the location was identified as Port Charles, New York in the 1970s.

In 1981, more Americans watched Luke and Laura's wedding than Prince Charles and Lady Diana's actual televised nuptials.

Jason Quartermaine was a clean-cut kid who wanted to be a doctor just like his dad, but everything changed after his alcoholic brother A.J. caused a drunk driving accident that left Jason with brain damage and memory loss. Almost overnight, he evolved into a stone-cold mob assistant who walked on the other side of Port Charles' tracks.

When David Hamilton's advances were rejected by the virtuous Dr. Lesley Webber, he began sleeping with her sixteen-year-old daughter Laura Webber instead. This torrid affair culminated in Laura killing her older lover after discovering that he was only using her to get back at her mother.

The Nurses Ball is one of Port Charles' most glamorous charity events dedicated to HIV/AIDS awareness and research.

When a very drunk AJ crashed his car into a strip club, Coutney agreed to strip for the club in order to pay off AJ's debt.

As a teenager, Luke accidentally killed his mother Lena Spencer with a baseball bat. He killed his father with a baseball bat too, but that was no accident.

After Luke and Laura successfully overthrew Mikkos Cassadine's scheme to rule the world, his widow Helena (then portrayed by Academy Award winning actress Elizabeth Taylor) secretly placed a curse on the couple during their reception.

In 2010, Sonny shot undercover cop Dominic Perelli, who turned out to be his own son Dante Falconeri.

Emily kept her breast cancer diagnosis secret until it was almost too late.